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I get it as there is always a guy who have questions on any topic.
raises hand
Name checks out
I read it as "the guy is so stupid he is lost already"
I dont get it either
I interpret it as "who is the arrow pointing at?" between the image and the prof.
Is it because of horns and utters together?
Apparently female cows (it's redundant yeah, but trying to be clear) DO grow horns, they just get cut off in captivity when they're calves: https://www.online-field-guide.com/do-female-cows-have-horns/
Whether Larson knew this and was drawing an anatomically accurate horned cow or was under the common misconception that cows lack horns and was trying to make a double layered joke about "someone has a stupid question about everything, even a simple picture of a cow" in conjunction with "but actually if you look closely enough there's something to question about this particular cow picture" I dunno.
So many layers