Somewhere during the Early Access Larian introduced the loaded / Karmic dice, to even out extreme effects of dice rolls. In EA this was enabled at default, and I assume the same will be true for the final release. It feels like it is a less pure D&D feature, since D&D gameplay is based on die rolls.
What do you think? Play with or without the Karmic Dice option enabled? And why?
Personally I will be playing without Karmic Dice. I believe Larian's concept behind it is like the DM that occasionally smudges the rolls during a game. The game is designed around you failing rolls just as much as succeeding so I will take what the dice wills.
That said people did testing during Early Access and found that on average you ended up hitting and getting hit more often in combat with Karmic Dice enabled as it sort of evens out your rolls. So if that interests you by all means go for it!