YouTube is running an experiment asking some users to disable their ad blockers or pay for a premium subscription, or they will not be allowed to watch videos.
YouTube is going to have a lot of trouble enforcing this. Lots and lots of people out there are going to be immediately at work finding ways around this limitation.
There will be some cat-and-mouse games with blockers and anti-blockers, but the "Nash equilibrium" end result of online ads is that they will be spliced with the content into a single video stream before being sent to you. It's not done now because it's less work for youtube servers not to re-encode, but it can and will be done if youtube clients/browsers with addons keep ignoring downloading the ad video files, or download them but lie about playing them. We'll come full circle back to television yet!
You'll need a DVR for your YouTube. Ironically, when DVRs were a thing for TV, the most reliable method for automatically skipping commercial breaks was cutting out segments with increased sound volume profile XD
The other alternative is total DRM and a war against general computing. We already have HDMI with HDCP encryption in place, next YouTube will demand that only trusted code (that guarantees ads are played) authenticated via a TPM on authorized devices can access their video streams. Netflix and Amazon are already doing it. I can't play either because my devices are too "free" for them.