The brain is a collection of single celled organisms cooperating for their collective survival and as a side effect generate a conscious person. The anger is the medium one lump of cells uses to communicate with another lump of cells.
My advice for avoiding headache is not to engage with this comment and drink some water to make sure it's not from dehydration.
No, not really. There are pretty fundamental differences between colonies of single celled organisms cooperating versus the cells of a multicellular organism.