We happy? Yeah, we happy.
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Step 1. Invent microplastics. Step 2. Have people ingest microplastics into their bodies. Step 3. Evolve plastic-eating mushrooms. Step 4. ??? Step 5. The Last of Us IRL
Those two dudes in the fenced off city led pretty great lives in The Last of Us. Everyone else suffered terribly though.
Step 6: Become a closeted prepper
That needs to be step 3 at the latest, otherwise you won't be prepared in time for step 5.