I use a 1tb ssd for the os/apps with my raid5 strictly for storage. Kinda nice if the os needs to be reinstalled or I want to migrate the raid cluster.
That's also a good option but I wouldn't with 6 drivers personally. I have a 12 bay array with two pools of 6 each running raidz2. I've run raid 5 for a long time but have had one drive fail many times and always have mini heart attacks while I wait for the new drive to come in and the rebuild process to happen.
I do this for expansion. I can expand the pool three drives at a time instead of 6. But, I set it up knowing the risk with a single parity drive...and I've acounted for that with backups. 👍