Denuvo identifies a user opening a game with multiple versions of Proton as multiple machines. It thinks that's piracy and locks the user out of the game
Denuvo's whole schtick is that your unique system environment gets used as a part of the "unlocking key" of sorts, so it would definitely not be simple. For example windows users face the same issue with denuvo whenever windows updates, although obviously that doesn't happen often enough to be an actual issue.