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I am right handed but I always use the Thinkpad nipple with my left hand. I tried switching the click buttons to make it properly left handed, but that made it way harder to use because then the primary click button sits on the right and I have to reach my thumb over. With the right handed settings my thumb is right on the button.
Re: Thinkpad nipple.
When I was a teenager, I had a laptop with a nipple and trackpad but no PS/2 port and no money to buy a proper USB mouse. So, I used the nipple to aim. Left hand nipple, right hand arrow keys.
Team Fortress Classic. Sniper.
Turns out pressure-based mouse sensitivity is a cheat code.
Edit: misremembered my config, which I looked up and corrected.
You can make the nipple pressure sensitive? How?
Push harder.
I use the trackpad on my MacBook with either hand, but like you I used my thinkpad nipple with my left hand.