Given as few intermediary as possible, which item takes the longest to handcraft in vanilla factorio?

Just asking, because I'm sitting here with modded factorio, and I'm waiting for some handcrafting to finish.

Sure, some of the intermediaries cannot be handcrafted, such as plastic and blue chips, so we'll say those are allowed.

Power armor mk2, probably? Anyone tried it to see how much time it takes?

Also, does the equation change if you have to handcraft any ingredients that go into an assembler to make the non-handcraftable ones?